Aiche Mohamed Amine2024-02-262024-02-262015-01-281995-0756http://dspace.univ-khenchela.dz:4000/handle/123456789/2082The present study has been carried out to elucidate the toxic effects of two commonly used pesticides, propiconazole, propineb and their mixture on reproductive parameters in male wistar rats. Twenty eight male rats were randomly divided into four groups. Rats in groups 2, 3, and 4 received propiconazole 60 mg/Kg, Propineb 100 mg/Kg and their mixture 30 mg/kg Propiconazole + 50 mg/kg Propineb, respectively, while those of group one served as control , and that throughout the 4 weeks experimental period. Animals were observed for clinical toxicity. At the end of treatment, all groups of animals were scarified and samples of different organs were fixed in the formol 10% for histopathological study. The semen study showed a decrease in the count and mobility of spermatozoa, accompanied with a significant decrease in morphological changes of flagellum in the treated groups especially with mixture compared to control group. It was also a decrease in the weight of the testis and epididymis in the treated groups compared to the control. Histological changes were observed in the testis and epididymis in all treated groups. In conclusion this paper shows clearly that the treatment with these pesticides alone or in combination for 4 weeks can induce a decrease in the quality of the sperm with histopathological changes in the testes and epididymis.enArticle