Boudjemaa BarizaRekkabe Fatima El-ZahraEncadreur-DEROUICHE.F2024-08-112024-08-112020-09576/27-Thttp://dspace.univ-khenchela.dz:4000/handle/123456789/6452Abstract Hemophilia is a rare inherited hemorrhagic disease of recessive transmission linked to the X chromosome. It is a severely debilitating disease due to the muscular and joint sequelae linked to the repetition of bleeding events involving the functional prognosis with sometimes life risk. This genetic anomaly, resulting in a deficiency most often constitutional in coagulation factor VIII (haemophilia A) or factor IX (haemophilia B). The role of these two factors in the general coagulation process allows us to better understand the clinical aspects of this disease. The treatment of hemophilia is complex and expensive, and the best treatment can be obtained through preventive health education. Despite the great progress that has been made in recent years in all aspects of the management of hemophilia patients, it continues to represent a real economic challenge for developing countries like Algeria. In this study, we are interested in the evaluation of the biological, genetic, evolutionary and therapeutic aspects of hemophiliacs.frThesis