Sofiane Habibatni2024-02-282024-02-282012-08-202249 – 4340http://dspace.univ-khenchela.dz:4000/handle/123456789/2338Abstract: The present study was undertaken to asses cicatrizing activity of a mixture of honey and Pistacia lentiscus fatty oil (PLFO) on dermal burn wounds. It was carried out on 8 male adult New Zealand rabbits. After anesthesia, 4 equal burns were realized on the back of each animal (2 dorsal and 2 lumbar). The wounds were treated, immediately after burning and repeated once daily until 22nd day of experiment, by 0.5 g of honey, 0.5 ml of PLFO or 0.5 g of mixture Honey + PLFO (v/v), the last wound was treated by 0.5 g of Cicatryl® as a reference drug. The healing process was evaluated by calculating the percentage of wound contraction at days 2, 6, 10, 14, 18 and 22. The results showed that both of honey, PLFO and the mixture honey + PLFO promote significantly (P<0.05) the wound contraction when compared to the standard drug at the different time intervals. In addition, PLFO showed better contraction than honey during the inflammatory and proliferative phases. The mixture showed a percentage of wound contraction better than that of honey but lower than that of PLFO used separately during the inflammatory phase, this difference became non significant at day 10 (P>0.05) and marked a significant reduction at the 14th day (P<0.05). After that the differences were not statically significant (P>0.05).In conclusion, the current study suggests that PLFO may ameliorate the healing properties of honey when mixed to it during the inflammatory phase of cicatrizing process in rabbit modelenArticle