Amina BOUGHOUGAL2024-02-112024-02-112018-12-04http://dspace.univ-khenchela.dz:4000/handle/123456789/410The development of structurally novel coordination compounds with diverse biological activity, such as antimicrobial, anti-inflammatory, antifungal, antioxidant and anticancer, is a rapidly evolving field of inorganic chemistry with potential for direct impact on improving the quality of life. Metal–drug complexes are of increasing interest in Bioinorganic Chemistry, leveraging the synergistic effect to lead to compounds with improved pharmacological activity. The recognition of the role of metal ions in biological systems and in treatment of various diseases calls attention to the benefits of studying the interaction of metal ions with organic drug molecules. In continuation with previous works of team, we focus here on the synthesis of new families of metal-antibiotic complexes associating, on one single-molecule, the antiseptic activity of a metal ion with the bioactivity of one or two type of bioactive molecules. Their additive actions have a synergetic effect and lead to more effective and shorter treatments and should strongly minimize the risks for appearance of bacteria mutants. In this work, we succeeded to synthesis the first metal-antibiotic complex associating two types of different antibiotic as ligands with Zn(II). The structure in the solid state of this new complex was established together with the studies of the chemical-physical properties. Comparative studies show it has a better antibacterial activity against (E.Coli, E,Aureus, E.Feacalis ) than parent antibiotics and complexes with only one of the antibiotic. This open a new concept named as Multi-Active Biomolecule Assembly. Moreover, the synthesis and characterisation of new trifluorométhylated antimicrobial ligands are described.frThesis