Rachid Thabet2024-02-282024-02-282019-01-071944-3986http://dspace.univ-khenchela.dz:4000/handle/123456789/2274Rivers receiving effluents from urban wastewater treatment plants are suspected to be among the main sources for the development and dissemination of multidrug-resistant bacteria into the environment. In the present study, we analyzed 15 river samples in order to assess the spread of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. One hundred eighty-eight Enterobacteriaceae were identified and classified as members of the genera Pantoea, Klebsiella, Escherichia, Enterobacter, Serratia, Yersinia, Providencia, and Shigella. Based on susceptibility results, the most part of isolates were highly resistant to the tested β-lactams (AMX, TIC AMC, and ATM), first-generation cephalosporins (CL), and second generation (FOX). ESBL production was determined by different methods, concluding its presence in 31.38% of the isolates by the disc approximation method, 25% by double-disk synergy test, and 28.72% by double-disk test. Given this situation, there is an urgent need to make more attention to the contamination of urban river by ESBL-producing bacteria, which constitute the main source of community infectionenArticle