Ameliorative Effect of Curcuma on Reproductive Functions of Male Adult Rats following Chromium Exposure Effet d’amélioration du curcuma sur les fonctions reproductrices des rats mâles adultes après exposition au chrome
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Date
2022
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Lavoisier SAS
Abstract
Abstract This study aimed to investigate the protective
effects of curcuma against hexavalent chromium-induced
alterations in reproduction indices of male Wistar rats.
Twenty adult maleWistar rats were divided into four groups.
The first group (0-0): control. The second group (0-Cur)
received a diet with 2% curcuma powder. The third group
(Cr-0) received 15 mg/kg B.W. of potassium dichromate
(K2Cr2O7) per os, while the last group (Cr-Cur) received a
diet containing 2% curcuma powder and 15 mg/kg B.W.
of K2Cr2O7 per os. After 30 days of treatment, testicular
weight, sperm concentration, sperm kinematic parameters,
and testicular glutathione (GSH) level were evaluated. Our
results suggest that hexavalent chromium causes a decrease
in sperm concentration, total progression, total motility, fast
motility, medium motility, slow motility, static sperm, linearity
(LIN), straightness (STR), amplitude of lateral head displacement
(ALH), beat cross frequency (BCF), sperm velocity,
and testicular GSH level, accompanied with an increase
in testicular weight and wobble (WOB) level when compared
to control group. However, supplementation with curcuma
of chromium-intoxicated rats has reduced the toxic
effect of K2Cr2O7 by bringing back the reproductive parameters
and GSH levels to normal values. From this finding,
it can be implicated that diet supplemented with curcuma
powder may show protective effects against chromium
toxicities.