Dendritic Cu(OH)2 nanostructures decorated pencil graphite electrode as a highly sensitive and selective impedimetric non‑enzymatic glucose sensor in real human serum blood samples
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Date
2022
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Monatshefte für Chemie - Chemical Monthly
Abstract
In this study, an efective and low price non-enzymatic electrochemical glucose sensor was easily elaborated through electrodeposition of highly uniform copper dendrites hydroxide onto pencil graphite electrode (Cu(OH)2/PGE). The obtained electrode was investigated by feld-emission scanning electron microscopy, atomic force microscopy, energy-dispersive X-ray spectroscopy, X-ray difraction, and FT-IR characterizations. The electrocatalytic properties of the modifed electrode were investigated by cyclic voltammetry, amperometry, and electrochemical impedance spectroscopy techniques, which can be readily applied to determine glucose using the fabricated sensor, as the results after optimization revealed. Furthermore, a single frequency impedance method was applied for glucose determination as an alternative to conventional EIS methods. The fabricated Cu(OH)2/PGE electrode exhibited a selective impedimetric response towards glucose over an exceptional linear range from 0.1 to 12 mM (R2 = 0.999) with a detection limit of 71.8 µM. Finally, Cu(OH)2/PGE was successfully applied to the assay of glucose in blood samples with unknown interferences.
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