Étude de l’hémophilie : aspects biologiques et génétiques
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Date
2020-09
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Publisher
Université Abbes Laghrour -Khenchela-
Abstract
Abstract
Hemophilia is a rare inherited hemorrhagic disease of recessive transmission linked
to the X chromosome. It is a severely debilitating disease due to the muscular and joint
sequelae linked to the repetition of bleeding events involving the functional prognosis with
sometimes life risk. This genetic anomaly, resulting in a deficiency most often
constitutional in coagulation factor VIII (haemophilia A) or factor IX (haemophilia B). The
role of these two factors in the general coagulation process allows us to better understand
the clinical aspects of this disease. The treatment of hemophilia is complex and expensive,
and the best treatment can be obtained through preventive health education. Despite the
great progress that has been made in recent years in all aspects of the management of
hemophilia patients, it continues to represent a real economic challenge for developing
countries like Algeria. In this study, we are interested in the evaluation of the biological,
genetic, evolutionary and therapeutic aspects of hemophiliacs.