Biological activities and phenolic compounds of olive oil mill wastewater from Abani, endemic Algerian variety

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dc.contributor.authorDalila Addad
dc.contributor.authorKenza Kadi
dc.date.accessioned2024-02-28T14:17:40Z
dc.date.available2024-02-28T14:17:40Z
dc.date.issued2022
dc.description.abstractThe current study aimed to determination of cytotoxicity, antioxidant, anti-inflammatory, anti- hemolytic, and anticoagulant activities of phenolic compounds extracted from olive oil mill wastewater (OMW) issue from the cold extraction of olive oil from Khenchela eastern in Algeria. The LC-MS (liquid chromatography-mass spectrometry) results were revealed the presence of 20 phenolic compounds in the extract of OMW and mostly consisted of Kaempferol, 4,5-di-O-caffeoyquinic acid, quinic acid, and caffeic acid. The extracts possessed effective reducing power (FRAP) and high radical scavenging activity against DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS + (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) free radicals, and it inhibited cytochrome c reduction in a dose-dependent manner. They exert a protective effect on red blood cells, and they were found to exhibit the highest inhibitory effect anti-inflammatory activity using inhibition of protein denaturation (IPD) and membrane stabilizing potential (MSP) tests (80.46±3.81 μg/mL and 87.43 ± 0.66 μg/mL) more than the standard used. The extract also showed the greatest anticoagulant activity in both the endogenous and exogenous routes (44.77 ± 0.25 s and 15.84 ± 0.12 s, respectively). Based on these findings, it is reasonable to infer that OMW is a good source of natural phenolic compounds with potential antioxidant, anti-inflammatory, and anticoagulant properties.
dc.identifier.urihttp://dspace.univ-khenchela.dz:4000/handle/123456789/2297
dc.language.isoen
dc.publisherNature
dc.titleBiological activities and phenolic compounds of olive oil mill wastewater from Abani, endemic Algerian variety
dc.typeArticle
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