Modulatory effect of curcuma against chromium-induced oxidative stress and physiological toxicity in rats
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Date
2022
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International Journal of Biosciences
Abstract
Chromium has long been identified as toxic environmental and industrial pollutants. The present study was
under taken to investigate the potential effect of curcuma on toxicity induced by hexavalent chromium in male
Wistar rats. Twenty-eight male rats were randomly divided into four equal groups. The first group: used as a
control group. The second group: given diet with 2% curcuma powder. The third group: given 15mg/kg B.W of
potassium dichromate (K2Cr2O7) per os, and the last group: given diet containing 2% curcuma powder and
15mg/kg B.W of K2Cr2O7 per os. The animals were in the same exposure conditions for 30 days. Organosomatic
indexes and glutathione (GSH) levels in studied organs were evaluated as well as the hematological
profile. The results indicate that administration of chromium caused noticeable increase in all studied organosomatic
indexes when compared to control group. Whereas, decreased GSH content in organs of chromiumexposed
rats was observed. Moreover, hematologic disorder was evidenced by significant decrease in plasma
red blood cells, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin
concentration (MCHC), mean corpuscular hemoglobin (CMH), and platelets along with significant increase in
white blood cells, neutrophils, lymphocytes and monocytes when compared to control group. However,
simultaneous treatment with curcuma and chromium corrected all the previous parameters. Data suggests
that curcuma acts as powerful antioxidant, ameliorates physiological and hematologic indices along with
oxidative stress biomarkers against chromium toxicity