Cycloartane glycosides from Astragalus gombo

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2015-01-21
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Six new cycloartane-type triterpene glycosides named 3-O-[b-D-glucopyranosyl(1 ! 2)-b-D-xylopyranosyl]-3b,16b,23(R),24(R),25-pentahydroxycycloartane (1), 3-O-[b-D-glucopyranosyl(1 ! 2)-b-Dxylopyranosyl]-3b,16b,23(R),24(R)-tetrahydroxy-25-dehydrocycloartane (2), 3-O-[b-D-xylopyranosyl]-6a-acetoxy-23a-methoxy-16b,23(R)-epoxy-24,25,26,27-tetranorcycloartane (3), 3-O-[b-D-xylopyranosyl]-6a-acetoxy-23a-butoxy-16b,23(R)-epoxy-24,25,26,27-tetranorcycloartane (4), 3-O-[b-Dglucopyranosyl(1 ! 2)]-b-D-xylopyranosyl]-6a-acetoxy-23a-methoxy-16b,23(R)-epoxy-24,25,26,27- tetranorcycloartane (5), 3-O-[b-D-glucopyranosyl(1 ! 2)]-b-D-xylopyranosyl]-23a-methoxy-16b,23(R)- epoxy-4,25,26,27-tetranorcycloartane (6), in addition to three known secondary metabolites consisting of another cycloartane triterpene glycoside and two flavonol glycosides, were isolated from the aerial parts of Astragalus gombo Coss. & Dur. (Fabaceae). The structures of the isolated compounds were established by spectroscopic methods, including 1D and 2D-NMR, mass spectrometry and comparison with literature data
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