SYNTHESE ET CARACTERISATION DE COMPOSES DE COORDINATION ANTIMICROBIENS
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Date
2018-12-04
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Amina BOUGHOUGAL
Abstract
The development of structurally novel coordination compounds with diverse biological
activity, such as antimicrobial, anti-inflammatory, antifungal, antioxidant and anticancer, is a
rapidly evolving field of inorganic chemistry with potential for direct impact on improving the
quality of life.
Metal–drug complexes are of increasing interest in Bioinorganic Chemistry, leveraging the
synergistic effect to lead to compounds with improved pharmacological activity. The
recognition of the role of metal ions in biological systems and in treatment of various diseases
calls attention to the benefits of studying the interaction of metal ions with organic drug
molecules.
In continuation with previous works of team, we focus here on the synthesis of new families
of metal-antibiotic complexes associating, on one single-molecule, the antiseptic activity of a
metal ion with the bioactivity of one or two type of bioactive molecules. Their additive
actions have a synergetic effect and lead to more effective and shorter treatments and should
strongly minimize the risks for appearance of bacteria mutants.
In this work, we succeeded to synthesis the first metal-antibiotic complex associating two
types of different antibiotic as ligands with Zn(II). The structure in the solid state of this new
complex was established together with the studies of the chemical-physical properties.
Comparative studies show it has a better antibacterial activity against (E.Coli, E,Aureus,
E.Feacalis ) than parent antibiotics and complexes with only one of the antibiotic. This open a
new concept named as Multi-Active Biomolecule Assembly. Moreover, the synthesis and
characterisation of new trifluorométhylated antimicrobial ligands are described.