Biochemical and Hematological Changes Following Long Term Exposure to Mancozeb
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Date
2015-01-09
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Advances in Bioresearch
Abstract
The aim of this study is to evaluate the effects of mancozeb; a carbamate fungicide on some hematological parameters
and some biochemical indices related to kidney and liver function. Male wistar rats were given different doses of
mancozeb orally: 500 and1000 mg/body weight/day for 8 weeks. The obtained results showed an increase in the
absolute weight of liver, spleen and kidneys, mainly in the group exposed to 1000 mg/ kg. Hematologic study revealed a
decrease in red blood cells hemoglobin and hematocrit values in all treated groups. However, white blood cells witnessed
an increase in all the treated groups. The biochemical tests revealed a rise in liver transaminases (AST / ALT), alkaline
phosphatase and total bilirubin serum, while total protein levels and total lipids have significantly decreased mostly in
group treated with 1000 mg/kg. Urea and creatinine have significantly increased in the group treated with 1000 mg/kg.
In the light of these results, it appears that chronic mancozeb exposure produced biochemical and hematological
changes of some parameters related to the liver and kidneys function