Biochemical and Hematological Changes Following Long Term Exposure to Mancozeb

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Advances in Bioresearch
The aim of this study is to evaluate the effects of mancozeb; a carbamate fungicide on some hematological parameters and some biochemical indices related to kidney and liver function. Male wistar rats were given different doses of mancozeb orally: 500 and1000 mg/body weight/day for 8 weeks. The obtained results showed an increase in the absolute weight of liver, spleen and kidneys, mainly in the group exposed to 1000 mg/ kg. Hematologic study revealed a decrease in red blood cells hemoglobin and hematocrit values in all treated groups. However, white blood cells witnessed an increase in all the treated groups. The biochemical tests revealed a rise in liver transaminases (AST / ALT), alkaline phosphatase and total bilirubin serum, while total protein levels and total lipids have significantly decreased mostly in group treated with 1000 mg/kg. Urea and creatinine have significantly increased in the group treated with 1000 mg/kg. In the light of these results, it appears that chronic mancozeb exposure produced biochemical and hematological changes of some parameters related to the liver and kidneys function