SUBCHRONIC MANCOZEB TREATEMENT INDUCED LIVER TOXICITY VIA OXIDATIVE STRESS IN MALE WISTAR RATS
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Date
2014
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Comm. Appl. Biol. Sci, Ghent University
Abstract
Mancozeb is a manganese/zinc ethyleneͲbisͲdithiocarbamate fungicide that is widely used in agriculture
to control a broad variety of fungal infections of both vegetables and ornamental plants. The present
study has been carried out to investigatethe possible effect of mancozeb on animal the oxidative stress
and some of the biochemical markers in male wistar rats. In this experiment, adult male rats weighing
between 200 and 250 g were treated per osfor 4 weeks with two different doses of 800 and 1200 mg/kg
per day. Reduced glutathione (GSH) levels were decreased in all treated groups compared to control ones.
It has been observed a significant increase in the fresh weight of liver in individuals of both doses. MoreͲ
over, mancozeb exposure caused a signiÞcant (pޒ0.05 (fall in aspartic aminotransferase (AST) and alanine
aminotransferase (ALT) in group treated with 1200 and 800 mg/kg/day. Similarly, alkaline phosphatase
(ALP) activity underwent a signiÞcant (pޒ0.05 (increase in both groups. The obtained observations clearly
reveal hepatotoxic effects of mancozeb in rats and constitute, therefore, an environmental health risks to
living organisms.