Synthesis, Crystal Structures, Hydrogen Bonds and Antibacterial Activity of New Quinoline Derivatives
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Date
2015-06-03
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Abstract
Two new quinolines derivatives where crystallized from the acetylation reaction in low temperature ;
between Baylis–Hillman products which had themselves been
prepared from the Meth Cohn method and catalyzed by 1,4-
diazabicyclo (Fatiha et al. in J Chem Crystallogr 42:989–996,
2012) octane and silicon dioxide or in pyridine and chloroform. Chemical structures have been established by spectral
techniques of FTIR, 1H NMR and X-ray single crystal in
low temperature. The crystal structure of (1a) crystallizes
in triclinic space group P-1, a = 7.9145(12) A˚ , b =
9.1412(11) A˚ , c = 10.7286(16) A˚ , a = 94.760(11) , b =
105.988(13) , c = 101.818(11) , while (2a) crystallizes inorthorhombic non- centrosymmetric space group Pna21,
a = 7.7237(12) A˚ , b = 20.2539(28) A˚ , c = 8.7164(12) A˚ ,
and its cohesion was found to be assured by O–HO and C–
HO hydrogen bonds. Antimicrobial activity (in vitro) was
evaluated by Gram-positive and Gram-negative bacteria. The
compounds have shown good biological activity with Grampositive bacteria (Staphylococcus aurous and Staphylococcus
coagulase-negative).
Graphical Abstract Two new Quinoline derivatives have
been prepared with good products yields; these products
constitute original compounds, of great interest biological
activity