Nephron-protective effects of curcuma on oxidative damage and oxidative stress in rat under sub-chronic poisoning of chromium
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Date
2019
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International Journal of Biosciences
Abstract
The aim of this study is to evaluate the nephroprotective role of Curcuma longa, against acute toxicity effects of hexavalent
chromium induced oxidative renal injury. Therefore, different antioxidant and serum biochemical parameters were measured.
Male Wistar rats were divided into four groups and were treated daily for 30 consecutive days. Group I (0-0): control rats
received mineral water through oral gavage (per os) and were nursed on normal diet. Group II (0-Cur): rats received mineral
water and were fed on an experimental diet containing 2 % of curcuma powder. Group III (Cr-0): rats were treated per os with
potassium dichromate at a dose of 15 mg/kg of body weight and were fed on normal diet. Group IV (Cr-Cur): rats received an
oral dose of potassium dichromate at a dose of 15 mg/kg of body weight and an experimental diet containing 2 % of curcuma
powder. Renal protein concentration, glutathione content, glutathione peroxidase, glutathione S-transferase and catalase
activities were estimated. Exposure of rats to chromium caused significant perturbation in the renal biomarkers (creatinine,
urea, uric acid, albumin, and total proteins), while there was a significant decrease in the oxidative stress parameters (GSH,
GPx, GST, and CAT). These disruptions were accompanied by histopathological changes in the kidney sections of rats
intoxicated with chromium, whereas treatment with Curcuma longa restored all the parameters mentioned above to near
normal. In conclusion, results revealed the potent antioxidants activity of curcuma that were demonstrated by its ameliorative
effects on chromium intoxication. Thus, this plant has a protective effect against nephron-damages induced by the hexavalent
chromium