Nephron-protective effects of curcuma on oxidative damage and oxidative stress in rat under sub-chronic poisoning of chromium

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International Journal of Biosciences
The aim of this study is to evaluate the nephroprotective role of Curcuma longa, against acute toxicity effects of hexavalent chromium induced oxidative renal injury. Therefore, different antioxidant and serum biochemical parameters were measured. Male Wistar rats were divided into four groups and were treated daily for 30 consecutive days. Group I (0-0): control rats received mineral water through oral gavage (per os) and were nursed on normal diet. Group II (0-Cur): rats received mineral water and were fed on an experimental diet containing 2 % of curcuma powder. Group III (Cr-0): rats were treated per os with potassium dichromate at a dose of 15 mg/kg of body weight and were fed on normal diet. Group IV (Cr-Cur): rats received an oral dose of potassium dichromate at a dose of 15 mg/kg of body weight and an experimental diet containing 2 % of curcuma powder. Renal protein concentration, glutathione content, glutathione peroxidase, glutathione S-transferase and catalase activities were estimated. Exposure of rats to chromium caused significant perturbation in the renal biomarkers (creatinine, urea, uric acid, albumin, and total proteins), while there was a significant decrease in the oxidative stress parameters (GSH, GPx, GST, and CAT). These disruptions were accompanied by histopathological changes in the kidney sections of rats intoxicated with chromium, whereas treatment with Curcuma longa restored all the parameters mentioned above to near normal. In conclusion, results revealed the potent antioxidants activity of curcuma that were demonstrated by its ameliorative effects on chromium intoxication. Thus, this plant has a protective effect against nephron-damages induced by the hexavalent chromium