Evaluation of putative cytotoxic activity of crude extracts from Onopordum acanthium leaves and Spartium junceum flowers against the U-373 glioblastoma cell line
| dc.contributor.author | Sofiane Habibatni | |
| dc.date.accessioned | 2024-02-28T22:01:16Z | |
| dc.date.available | 2024-02-28T22:01:16Z | |
| dc.date.issued | 2015-07 | |
| dc.description.abstract | Abstract: Crude hydromethanolic (80% methanol) extracts produced by maceration of Onopordum acanthium leaves and Spartium junceum flowers were tested for cytotoxic effects against glioblastoma U-373 tumour cells. Onopordum acanthium extract was found to be ~5 times more cytotoxic than Spartium junceum (IC50 values of 309 and 1602μg/ml, respectively). Similar to most chemotherapeutic agents killing through the intrinsic pathway, Onopordum killed the cells via apoptosis, which was confirmed by the activation of caspase-3. Spartium exerted its weak cytotoxic effect, presumably by a caspase-independent, non-apoptotic form of necrotic-like programmed cell death. Onopordum acanthium is considered a promising plant for the researchers investigating putative biological activities, particularly antitumour and immune-related activity | |
| dc.identifier.uri | http://dspace.univ-khenchela.dz:4000/handle/123456789/2336 | |
| dc.language.iso | en | |
| dc.publisher | researchgate | |
| dc.title | Evaluation of putative cytotoxic activity of crude extracts from Onopordum acanthium leaves and Spartium junceum flowers against the U-373 glioblastoma cell line | |
| dc.type | Article |
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