Thyroid Disruption and Infertility after Chronic Exposure to Mancozeb
| dc.contributor.author | Aiche Mohamed Amine | |
| dc.date.accessioned | 2024-02-26T20:06:59Z | |
| dc.date.available | 2024-02-26T20:06:59Z | |
| dc.date.issued | 2015-04-19 | |
| dc.description.abstract | This work aims to highlight the toxic effects of mancozeb; polymeric complex of manganese and zinc ethylene bis-dithiocarbamate, on the fertility and thyroid functions. Male Wistar rats were treated orally with different doses of mancozeb: 250, 500 and 1000 mg/kg body weigh/ day for 8 weeks. The obtained results showed a highly significant increase (p≤ 0.01) on thyroid absolute weight in the groups treated with 500 and 1000 mg/kg body weight/day respectively. However, testes absolute weight witnessed a significant decrease (p≤ 0.05) in group treated with 500 mg/kg, this decrease becomes very highly significant in the group treated with 1000 mg/kg/day. The biochemical test revealed a significant increase of cholesterol and triglycerides rates in the group treated with the highest dose. A highly significant increase of blood glucose is also observed in the groups treated with 500 and 1000 mg /kg/day. Hormone assays have shown a very highly significant decrease of thyroxine in all the groups treated with different doses, while triiodothyronine concentration witnessed a very highly significant decrease only in the group treated with 1000 mg/kg/day. Finally, the studying of biological characters of the spermatozoa showed a highly significant and very highly significant decrease in the concentration of spermatozoa and their mobility in rats treated with 500 and 1000 mg/kg/day respectively. In conclusion, it seems that long term exposure to mancozeb is associated to hypothyroidism by decreasing FT4 and FT3 and has adverse effects on testes function leading to physiological impairment. | |
| dc.identifier.issn | 1995-0756 | |
| dc.identifier.uri | http://dspace.univ-khenchela.dz:4000/handle/123456789/2084 | |
| dc.language.iso | en | |
| dc.publisher | Advances in Environmental Biology | |
| dc.title | Thyroid Disruption and Infertility after Chronic Exposure to Mancozeb | |
| dc.type | Article |