Therapeutic potential of Hyoscyamus niger-derived compounds: Targeting ovarian cancer through antioxidant activity and EGFR tyrosine kinase inhibition
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Date
2024
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of King Saud University - Science
Abstract
Ovarian cancer poses a significant challenge to women’s health, necessitating innovative therapeutic approaches.
This study investigates the therapeutic potential of compounds derived from Hyoscyamus niger, a medicinal plant
with a history of traditional use, focusing on their antioxidant properties and their ability to inhibit epidermal
growth factor-receptor (EGFR) tyrosine kinase a promising target in cancer therapy. LC-ESI-MS/MS analysis of
H. niger extract revealed the presence of 21 phenolic compounds, with luteolin and p-coumaric acid notably
exhibiting the highest concentrations. The extract displayed robust antioxidant activity across multiple assays,
and its performance in the Reducing Power assay highlights its potential in reducing oxidative stress. Molecular
docking results indicate that several phenolic compounds may serve as EGFR inhibitors, offering promising
avenues for further investigation in cancer therapy. Notably, hyperoside emerged as a strong candidate due to its
favorable binding energy and interactions within the EGFR active site. This study demonstrates the therapeutic
promise of H. niger-derived compounds in targeting ovarian cancer through antioxidant activity and EGFR inhibition.
Further
research
is
warranted
to
validate
their
efficacy
and
safety,
potentially
opening
up
new
avenues
for
ovarian
cancer
treatment.