Preliminary study to assess cicatrizing activity of honey and Pistacia lentiscus fatty oil mixture on experimental burns in rabbits
No Thumbnail Available
Date
2012-08-20
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
researchgate
Abstract
Abstract: The present study was undertaken to asses cicatrizing activity of a mixture of honey and Pistacia lentiscus
fatty oil (PLFO) on dermal burn wounds. It was carried out on 8 male adult New Zealand rabbits. After anesthesia, 4
equal burns were realized on the back of each animal (2 dorsal and 2 lumbar). The wounds were treated, immediately
after burning and repeated once daily until 22nd day of experiment, by 0.5 g of honey, 0.5 ml of PLFO or 0.5 g of mixture
Honey + PLFO (v/v), the last wound was treated by 0.5 g of Cicatryl® as a reference drug. The healing process was evaluated
by calculating the percentage of wound contraction at days 2, 6, 10, 14, 18 and 22. The results showed that both of
honey, PLFO and the mixture honey + PLFO promote significantly (P<0.05) the wound contraction when compared to
the standard drug at the different time intervals. In addition, PLFO showed better contraction than honey during the inflammatory
and proliferative phases. The mixture showed a percentage of wound contraction better than that of honey
but lower than that of PLFO used separately during the inflammatory phase, this difference became non significant at day
10 (P>0.05) and marked a significant reduction at the 14th day (P<0.05). After that the differences were not statically
significant (P>0.05).In conclusion, the current study suggests that PLFO may ameliorate the healing properties of honey
when mixed to it during the inflammatory phase of cicatrizing process in rabbit model