New unsymmetrically substituted triazacyclohexanes: Synthesis, characterisation, antimicrobial properties and DFT study
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Date
2016-09-21
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Abstract
New five unsymmetrically substituted 1,3,5-triazacyclohexanes compounds, carrying aliphatic as well as
aromatic substituent, were synthesized and structural analyses were performed by FTIR, 1H NMR and
single crystal X-ray techniques. Experimental research was complemented by quantum mechanical
calculations. The present triazacyclohexane rings adopt a chair conformation by both R1 substituents in
axial positions and R2 group in an equatorial form. Further, all compounds were screened for their antibacterial and anti-fungal properties. By revealing further insight into triazacyclohexanes systems, the
data theoretically predicted and experimentally obtained in current research may be helpful guide for
the medicinal chemists.