Browsing by Author "Saidi Malika"

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    Ameliorative Effect of Curcuma on Reproductive Functions of Male Adult Rats following Chromium Exposure Effet d’amélioration du curcuma sur les fonctions reproductrices des rats mâles adultes après exposition au chrome
    (Lavoisier SAS, 2022) Saidi Malika
    Abstract This study aimed to investigate the protective effects of curcuma against hexavalent chromium-induced alterations in reproduction indices of male Wistar rats. Twenty adult maleWistar rats were divided into four groups. The first group (0-0): control. The second group (0-Cur) received a diet with 2% curcuma powder. The third group (Cr-0) received 15 mg/kg B.W. of potassium dichromate (K2Cr2O7) per os, while the last group (Cr-Cur) received a diet containing 2% curcuma powder and 15 mg/kg B.W. of K2Cr2O7 per os. After 30 days of treatment, testicular weight, sperm concentration, sperm kinematic parameters, and testicular glutathione (GSH) level were evaluated. Our results suggest that hexavalent chromium causes a decrease in sperm concentration, total progression, total motility, fast motility, medium motility, slow motility, static sperm, linearity (LIN), straightness (STR), amplitude of lateral head displacement (ALH), beat cross frequency (BCF), sperm velocity, and testicular GSH level, accompanied with an increase in testicular weight and wobble (WOB) level when compared to control group. However, supplementation with curcuma of chromium-intoxicated rats has reduced the toxic effect of K2Cr2O7 by bringing back the reproductive parameters and GSH levels to normal values. From this finding, it can be implicated that diet supplemented with curcuma powder may show protective effects against chromium toxicities.
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    Modulatory effect of curcuma against chromium-induced oxidative stress and physiological toxicity in rats
    (International Journal of Biosciences, 2022) Saidi Malika
    Chromium has long been identified as toxic environmental and industrial pollutants. The present study was under taken to investigate the potential effect of curcuma on toxicity induced by hexavalent chromium in male Wistar rats. Twenty-eight male rats were randomly divided into four equal groups. The first group: used as a control group. The second group: given diet with 2% curcuma powder. The third group: given 15mg/kg B.W of potassium dichromate (K2Cr2O7) per os, and the last group: given diet containing 2% curcuma powder and 15mg/kg B.W of K2Cr2O7 per os. The animals were in the same exposure conditions for 30 days. Organosomatic indexes and glutathione (GSH) levels in studied organs were evaluated as well as the hematological profile. The results indicate that administration of chromium caused noticeable increase in all studied organosomatic indexes when compared to control group. Whereas, decreased GSH content in organs of chromiumexposed rats was observed. Moreover, hematologic disorder was evidenced by significant decrease in plasma red blood cells, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (CMH), and platelets along with significant increase in white blood cells, neutrophils, lymphocytes and monocytes when compared to control group. However, simultaneous treatment with curcuma and chromium corrected all the previous parameters. Data suggests that curcuma acts as powerful antioxidant, ameliorates physiological and hematologic indices along with oxidative stress biomarkers against chromium toxicity
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    Nephron-protective effects of curcuma on oxidative damage and oxidative stress in rat under sub-chronic poisoning of chromium
    (International Journal of Biosciences, 2019) Saidi Malika
    The aim of this study is to evaluate the nephroprotective role of Curcuma longa, against acute toxicity effects of hexavalent chromium induced oxidative renal injury. Therefore, different antioxidant and serum biochemical parameters were measured. Male Wistar rats were divided into four groups and were treated daily for 30 consecutive days. Group I (0-0): control rats received mineral water through oral gavage (per os) and were nursed on normal diet. Group II (0-Cur): rats received mineral water and were fed on an experimental diet containing 2 % of curcuma powder. Group III (Cr-0): rats were treated per os with potassium dichromate at a dose of 15 mg/kg of body weight and were fed on normal diet. Group IV (Cr-Cur): rats received an oral dose of potassium dichromate at a dose of 15 mg/kg of body weight and an experimental diet containing 2 % of curcuma powder. Renal protein concentration, glutathione content, glutathione peroxidase, glutathione S-transferase and catalase activities were estimated. Exposure of rats to chromium caused significant perturbation in the renal biomarkers (creatinine, urea, uric acid, albumin, and total proteins), while there was a significant decrease in the oxidative stress parameters (GSH, GPx, GST, and CAT). These disruptions were accompanied by histopathological changes in the kidney sections of rats intoxicated with chromium, whereas treatment with Curcuma longa restored all the parameters mentioned above to near normal. In conclusion, results revealed the potent antioxidants activity of curcuma that were demonstrated by its ameliorative effects on chromium intoxication. Thus, this plant has a protective effect against nephron-damages induced by the hexavalent chromium
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    Protective Effect of Curcuma Against Chromium Hepatotoxicity in Rats L’effet protecteur de curcuma contre l’hépatotoxicité du chrome chez les rats
    (Lavoisier SAS, 2020) Saidi Malika
    Abstract This study was carried out to investigate the antioxidant effects of curcuma against chromium-induced alterations in hepatic indices and dysfunctions in the antioxidant system. Forty male Wistar rats were randomly divided into four groups and were treated for 30 consecutive days. The control group (0-0) received per os mineral water and normal diet. The second group (0-Cur) received mineral water and an experimental diet containing 2% of curcuma powder, whereas the third group (Cr-0) was orally fed (per os) with 15 mg/kg body weight/day of potassium dichromate and normal diet. The last group (Cr-Cur) received per os 15 mg/kg of potassium dichromate and a diet with 2% of curcuma. The treatment by chromium was found to elicit a perturbation in biochemical parameters producing a significant increase in glycemia, triglycerides, cholesterol, ALP, ALT, AST, and LDH levels. On the contrary, a significant reduction was observed in the oxidative stress-related parameters (GSH, GPx, CAT, and GST). Moreover, we noticed that liver sections of rats intoxicated with chromium showed a disrupted architecture. However, the administration of curcuma revealed an intense reduction in the oxidative stress induced by chromium, ameliorating the levels of the majority of the previous parameters. The data of this study revealed the potent antioxidant effects of curcuma in reducing oxidative stress damage induced by the hexavalent chromium.Wistar ont été divisés en quatre groupes de dix rats chacun, puis traités quotidiennement pendant 30 jours consécutifs. Le groupe témoin (0-0) recevant de l’eau minérale per os et un régime alimentaire normal. Le deuxième groupe (0- Cur) recevant de l’eau minérale et un régime alimentaire contenant 2 % de curcuma, tandis que le troisième groupe (Cr-0) a reçu per os 15 mg/kg de poids corporel par jour de dichromate du potassium et un régime normal. Le dernier groupe (Cr-Cur) recevant per os 15 mg/kg de dichromate du potassium et un régime alimentaire à 2 % de curcuma. Le traitement au chrome a provoqué une perturbation des paramètres biochimiques se traduisant par une augmentation significative de la glycémie, des triglycérides, du cholestérol, des TGP, des TGO, de la PAL et de la LDH. Toutefois, une réduction significative des paramètres liés au stress oxydatif (GSH, GPx, CAT et GST) a été observée. Par ailleurs, les différentes coupes histologiques hépatiques des rats traités par le chrome ont montré une architecture tissulaire perturbée. Cependant, l’administration du curcuma a démontré une réduction intense du stress oxydatif induit par le chrome, améliorant ainsi la majorité des paramètres biochimiques et histologiques précédents. Les données de cette étude ont révélé les puissants effets antioxydants et hépatoprotecteurs du curcuma contre les dommages oxydatifs et les altérations induits par l’administration du chrome.