Browsing by Author "OUMAIMA NAILI"

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    Acute Toxicity Study of Abies numidica Extracts in Broiler Chickens
    (Indian Journal of Novel Drug Delivery, 2021-12-24) OUMAIMA NAILI
    The aim of this study was to assess in vivo acute toxicity of hydroalcoholic and aqueous extracts of Algerian fir needles (Abies numidica) in broiler chickens. Total 18 one-day-old broiler chicks were obtained from hatchery. At three weeks of age chickens were weighed and separated into 3 groups. The control group received only distilled water, while treatment groups were orally administered 2000 mg.kg-1b.wt. of hydroalcoholic and aqueous extracts of Abies numidica. No mortality or significant changes were observed in body weight, feed intake and feed conversion. Also, Blood parameters and relative organ weights were normal. Microscopic observations of liver and kidneys tissues of treatment and control group were similar. In conclusion, acute toxicity test indicated that extracts were not toxic when administered by the oral route to broiler chickens at 2000 mg.kg1b.wt.
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    In Vitro Antimicrobial Activity of Mentha piperita Leaves Extracts
    (Indian Journal of Novel Drug Delivery, 2022-12-26) OUMAIMA NAILI
    M. piperita (Lamiaceae family) have been used as traditional remedies for the treatment of several diseases. In this work, we aimed to characterize the antimicrobial activity of extracts of Mentha piperita leaves. Various extracts (methanolic and aqueous) were analysed for their phenolic content and antimicrobial activity. This was done by the method of diffusion against three Gram+ (Staphylococcus aureus ATCC 25923, Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 and Bacillus subtilis ATCC6633) and three Gram- (Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922 and Salmonella typhi ATCC 14028) strains and a yeast (C. albicans ATCC 1024). On the other hand, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of active extracts; were determined by using the dilution method on solid medium. The results indicate that the leaves extracts are rich in polyphénols. On the other side, the Antimicrobial tests exhibited different activities depending on the strain used and the nature of the extract (methanol or aqueous). MRSA was the most sensitive since its growth was inhibited by both extracts with the widest diameter of 23.5mm, whereas Gram-negative bacteria and the yeast C. albicans were the most resistant. The results of the MIC and the MBC of active extracts showed that both extracts (methanolic and aqueous) of leaves showed the best activity against SARM (MIC: 8mg/ml; MBC: 10mg/ml). Determination of total phenols and flavonoids suggested that the antibacterial activity is attributed mainly to the richness of this plant in phenolic compounds. These preliminary results may justify the use of this plant in the treatment of certain bacterial diseases and that phenolic compounds may be exploited for therapeutic purposes, especially antibacterial.