Browsing by Author "Messai Amel"

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    Crystal structure of 3-[4-(1-methylethyl)- phenyl]-1-(naphthalen-2-yl)prop-2-en-1- one
    (2014-07-30) Messai Amel
    The title compound, C22H20O, was synthesized by reacting 4- isopropylbenzaldehyde with 2-acetonaphtone by aldolic condensation under Claisen–Schmidt conditions. The molecule consists of a naphthalene group and a benzene ring with a pendant isopropyl moiety, both rings bound by a propenone linker. The naphthalene ring system is almost planar [maximum deviation from the least-squares plane = 0.026 (10) A˚ ] and subtends a dihedral angle of 52.31 (4) with the benzene ring. The propenone linker, in turn, deviates slightly more from planarity [maximum deviation = 0.125 (18) A˚ ] and has its least-squares plane oriented midway the former two, at 25.62 (6) and 28.02 (5) from the naphthalene ring system and the benzene ring, respectively. Finally, the isopropyl group presents its CC2 plane almost perpendicular to the benzene ring, at 85.30 (4) . No significant hydrogen bonding or – stacking interactions are found in the crystal structure
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    Synthesis, Characterizations, and Biological Effects Study of Some Quinoline Family
    (2016) Messai Amel
    The objective of this work is the synthesis of new quinoline molecules which could have some biological activities. This chapter reported a new approach to the synthesis of some quinoline derivatives. The Baylis-Hillman reaction on 2-methoxy-3-formyl quinoléines derivatives have applied in order to obtain Baylis-Hillman adducts. The products are characterized by FTIR, NMR and X-ray single crystal diffraction .Also, a study of the antibacterial activity of the 3-(2-chloro quinoline)-3-hydroxy-2 methylene propanonitrile products synthesized have been explored. This assessment is made by using the disk diffusion method. The results showed that the 3-(2’-chloroquinoline)-3-hydroxy-2-methylenepropanonitril derivatives present a good antibacterial effectiveness against the strains tested Gram-positive and no antibacterial potency was observed against the stains Gram-negative used in the test.