Browsing by Author "Meriem Krim"

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    Ginger-supplemented diet ameliorates ammonium nitrate-induced oxidative stress in rats
    (African Journal of Biotechnology, 2013-09-06) Meriem Krim
    The present study was designed to evaluate the capacity of ginger to repair the oxidative stress induced by ammonium nitrate. 50 male rats were divided into 5 groups; they underwent an oral treatment of ammonium nitrate and/or ginger (N mg/kg body weight + G% in diet) during 30 days. Group I served as control (C); group II (G) received a diet with 2% of ginger; group III (N) received a toxic dose of ammonium nitrate and normal diet; group IV (NG) received a toxic dose of ammonium nitrate and a diet containing 2% ginger and group V (N+G) received a highly toxic dose of ammonium nitrate and an experimental diet containing 2% ginger. The treatment by ammonium nitrate was found to elicit a rise in blood biochemical parameters, a disorder in hematological parameters and significant decrease in the tissue glutathione level. Feeding ginger supplemented diets to ammonium nitrate treated rats restored all the parameters studied compared to the controls. These findings suggest that ginger treatment exerts a protective effect on metabolic disorders by decreasing oxidative stress.
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    Protective effect of ginger against toxicity induced by chromate in rats
    (jle,com, 2013) Meriem Krim
    Abstract : The evaluation of the effect of ginger on the modulation of toxic effects induced by chromate is the objective of our study. 50 male rats Albinos wistar were divided to five groups as follow: group I (T) is served as control, received a mineral water by gavage (per os); group II (G) received an experimental diet with 2% of ginger; group III (Cr) received an oral dose of potassium dichromate (15 mg/kg) and normal diet; group IV (CrG): received an oral dose of potassium dichromate (15 mg/kg) and an experimental diet containing 2% ginger; and group V (Cr+G) received an oral dose of potassium dichromate (25 mg/kg) and an experimental diet with 2% of ginger. The results of this study indicate that the chromate provoked a haematoxic effect (anemia), nephrotoxic, hepatotoxic, and also a perturbation in lipids profile. In addition, chromate has a pro-oxidant effect, which was indicated by decrease of reduced glutathione (GSH) levels in different tissues. However, the administration of ginger revealed a reduction of the intensity of oxidative stress induced by the chromate resulting in the decrease of the majority of the previous parameters concentrations. In conclusion we demonstrated that ginger has potent antioxidants activity, revealed by the amelioration of chromate’s toxic effects.We can say that ginger has a protective effect towards damages induced by the chromate.