Browsing by Author "Hanane Lamraoui"

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    A comparative study of two novel unsymmetrically substituted triazacyclohexanes
    (2017-02-27) Hanane Lamraoui
    Novel unsymmetrically N-substituted N,N0-R1N00-R2-1,3,5-triazacyclohexanes (1b and 2b; R1 ¼ p-chlorophenyl or p-methoxyphenyl and R2 ¼ butyl or cyclohexyl) have been synthesized in a good yield from condensation reaction by excess amine. Both triazacyclohexane rings have chair conformation. However, 1b adopts diaxial orientation of aryl groups and an equatorial form of alkyl group whereas 2b prefers an axial orientation of the alkyl group and diequatorial forms of aryl groups. 1b is consolidated by weak CH/p interactions. Intra-molecular C-H/O or C-H/N hydrogen bonds and C-H/p may be effective in the stabilization of 2b. Both compounds have showed moderate antimicrobial activity, but 1b exhibits higher activity than 2b. All experimental results are found in good support to theoretical data. Findings of research may be helpful guide for the medicinal chemists and the field is further open for pharmacokinetics studies.
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    DL-Leucinium nitrate
    (2005-04-30) Hanane Lamraoui
    he crystal structure of dl-2-ammonium-4-methylvaleric acid nitrate (C6H14NO2+ NO3ÿ, dl-leucinium nitrate) can be described by considering two types of layers parallel to the bc plane: hydrophilic layers including the head of the leucinium residue (ammonium and carboxylic groups) with the nitrate anion, and hydrophobic layers including the tail of the leucinium residue
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    Hydrogen bonding in creatininium nitrate Fadila Berrah, Hanane Lamraoui and Nourredine Benali-Cherif
    (2005-01-08) Hanane Lamraoui
    In the title compound, C4H8N3O+ NO3ÿ, creatininium cations and nitrate anions are linked to each other through strong hydrogen bonds, formed by all H atoms covalently bonded to the N atoms. Short contacts are also observed between the anions. This complex three-dimensional network of hydrogen bonds ensures the cohesion of the ionic structure.