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Browsing scientific events by Author "BENDJEMANA KATIA"

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    ASSOCIATION BETWEEN GENETIC POLYMORPHISMS OF HUMAN CYTOCHROME CYP2E1 AND RISK OF NASOPHARYNGEAL CARCINOMA IN ALGERIA POPULATION
    (International Journal of Pharmacy and Pharmaceutical Sciences, 2018-03-08) BENDJEMANA KATIA
    ABSTRACT Objective: The present study was carried out to analyze the relationship between CYP2E1 genetic polymorphism and the risk of developing nasopharyngeal cancer (NPC). Methods: The study involved 100 patients with nasopharyngeal carcinoma, compared with 180 healthy controls. Genomic DNA samples were assayed for restriction fragment length polymorphisms in the CYP2E1 by PCR amplification followed by digestion with RsaI. The frequency comparison between the two groups was determined by the χ(2) test. Results: Our results showed that the distribution of CYP2E1-/-allele frequency was found to be significantly different between controls (22 %) and cancer cases (26%) along with twice increase of the NPC risk in Algeria (OR=2.2, CI 95% [1.02-2.54]). Conclusion: Our results are in line with those found for other populations and subsequent they emphasize the importance of the involvement of this gene in the development of the NPC detoxification process, which exhibited more and more strong association with environmental factors.
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    N-Acetyltransferase 2, glutathione S-transferase gene polymorphisms and susceptibility to hepatocellular carcinoma in an Algerian population
    (trading as Taylor & Francis Group, 2022-02-16) BENDJEMANA KATIA
    ABSTRACT 1. This study was conducted to investigate the potential association of genetic polymorphisms of glutathione S-transferase M1/T1 (GSTM1, GSTT1), and N-acetyltransferase 2 (NAT2) genes and epidemiological parameters with the risk of HCC in the Algerian population. 2. A case-control study including 132 confirmed HCC patients and 141 cancer-free controls was performed. Genotyping analysis was performed using conventional multiplex PCR and PCR-RFLP. Statistical analysis was performed using the Chi-square test. Logistic regression analysis was used to estimate odds ratios and 95% confidence intervals (95% CI). 3. GSTM1 null and NAT2 slow acetylator genotypes confer an increased risk to HCC (OR ¼ 1.88, 95% CI 1.16–3.05; OR ¼ 2.30, 95% CI 1.26–4.18, respectively). This association was prevalent in smokers (OR ¼ 2.00, 95% CI 1.05–3.8 and OR ¼ 2.55, 95% CI 1.22–5.34, respectively). No significant association was observed for GSTT1 null genotype in the contribution to HCC risk (OR ¼ 0.76, 95% CI 0.46–1.27). 4. In conclusion, the GSTM1 and NAT2 gene polymorphisms are positively associated with the risk of HCC in older men and especially in smokers.